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Methylphenidate is a stimulants that activate, enhance, or increase activity of the central nervous system.

It has a notably calming and “focusing” effect on those with attention-deficit hyperactivity disorder (ADHD), particularly in children.

Research shows that individuals with ADHD do not become addicted to stimulant medications when taken in the form and dosage prescribed by doctors.

Side Effects

  • Depression, dizziness, drowsiness, headache, sleep disturbance.
  • Change in blood pressure or heart beat.
  • Hair loss, rash
  • Growth retardation
  • Blurred vision
  • Weight loss, nausea, vomiting

Adverse Effects

In recent years there are reports of methylphenidate abused by some people for its stimulant properties such as appetite suppression, wakefulness, increased focus/attentiveness, and euphoria.

Some abusers may have the complications if they dissolve the tablets in water and inject the mixture into themselves because insoluble fillers in the tablets can block small blood vessels.


  • Take exactly as directed.
  • Do not change dosage or discontinue without consulting doctor.
  • Response may take some time.
  • Do not crush or chew tablets.
  • Tablets and sustained release tablets should be taken 30-45 minutes before meals.
  • Some medications may have different method of administration. You have to read the instructions carefully.
  • Maintain adequate fluid intake unless you are instructed to restrict fluid intake.
  • You may experience decreased in appetite or weight loss. Small frequent meals may help to maintain adequate nutrition.
  • The medication may cause dizziness or restless, especially during early therapy. Avoid driving or engaging in tasks requiring alertness when you are on this medication.


  • High blood pressure
    • Monitor blood pressure
  • History of epilepsy
    • Inform the doctor if convulsions occur
  • Growth retardation if prolonged therapy without medical supervision
    • Monitor height and weight
  • Avoid abrupt withdrawal

Additional Information

Inform the doctor if the medication’s effect wears off in the evening.

Tell your doctor if you have medical problems like hypertension, glaucoma or hyperthyroidism.

This medication is not recommended in pregnant women or breast feeding mother.

It is not recommended to the patient with the history of drug or alcohol abuse.

Storage Conditions

Since these drugs are often abused, extra caution should be taken in storing them.

Do not mix them with other medicines.

Keep medicines in a cool, dry place and out of a child’s reach.


Last reviewed : 20 April 2012
Writer : Yam Chiew Fong
Reviewer : Rabi’ah bt. Mamat