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Hipertension in Pregnancy

Introduction

Hypertension is the commonest medical disorder in pregnancy.

  1. pre-existing hypertension,
  2. pregnancy-induced hypertension and
  3. pre-eclampsia

Pre-existing hypertension affects 1 to 5% of pregnancies whereas Pregnancy Induced Hypertension occurs in 5 to 10% of all pregnancies. This figure could be higher in Asian countries due to the genetic predisposition. Gestational Hypertension can be as common as 25% in the first pregnancy.

Hypertension in pregnancy needs close monitoring and treatment. Mothers with hypertension have a high risk of getting Pre-Eclampsia and Eclampsia (seizure) which can cause brain and kidney damage, blood disorders and detrimental effects to the unborn fetus.

Why does hypertension in pregnancy occur?

Nobody has yet to discover the actual reason why some mothers develop hypertension whilst others don’t. Risk factors involve genetic predisposition. It has been postulated that there is a problem with the development of placenta during the first half of pregnancy. Inappropriate inflammatory response produced by the body against the placenta was also thought to be a possible mechanism. It was reported that more Asian women suffer from hypertensive disorders in pregnancy.

Who are at risk?

Below is a list of risk factors for hypertension in pregnancy.

General

  • Women age above 40
  • Obesity. BMI < 30 is associated with an approximately double the risk of pre-eclampsia. High BMI pre-pregnancy or in early pregnancy generally will increase the risk of hypertension in pregnancy

Genetic Factors

  • History of hypertensive disorders in pregnancy on neither maternal side nor siblings increased the risk between 20-40%.

Obstetric Factors

  • Primigravida – first pregnancy (2-3 fold risk)
  • Multiple pregnancy
  • Previous pre-eclampsia
  • Long birth interval (longer spacing)
  • Hydrops with a large placenta
  • Hydatidiform mole

Just a note, although the primigravida mothers have high risk of pre-eclampsia, it is the multiparous women develop more severe disorders with multiple complications.

Medical Factors

  • Pre-existing hypertension
  • Kidney disease
  • Diabetes
  • Antophospolipid antibodies
  • Connective tissue disease
  • Inherited thrombophilia


BP measuring equipment is used for a standard measurement of blood pressure

When does hypertension occur in pregnancy?

Hypertension can occur any time during the pregnancy and that is why BP measurement is taken each time antenatal mothers attend the health clinic.

Pre-existing Hypertension in Pregnancy

Pre-existing hypertension is noted early in the pregnancy during the first trimester. Commonly hypertension is asymptomatic thus individual may not know the raised BP until she falls pregnant and the high BP is picked up during a routine antenatal visit. Young individuals with raised BP should not be taken for granted and labeled as Essential Hypertension. Investigations must be looked further for possibility of secondary causes like Cushing’s syndrome, Conn’s Syndrome and phaeochromocytoma. Women with pre-existing hypertension from whatever cause are at increased risk of super imposed pre-eclampsia, small for gestational age (SGA) infants and placental abruption. A woman with hypertension prior to pregnancy requires treatment because the risk of pre-eclampsia in pregnancy is approximately doubled.

Pregnancy-Induced Hypertension

In contrast, pregnancy-induced hypertension and pre-eclampsia usually appear in the second half of pregnancy and resolve within 6 weeks of delivery. BP may remain elevated up to 3 months post partum. Pregnancy-induced hypertension may be defined as hypertension occurring in the second half of pregnancy but in the absence of features of pre-eclampsia (described below). Treatment for both pre-existing hypertension and pregnancy-induced hypertension is the same. If hypertension develops after 20 weeks, the likelihood of progression to pre-eclampsia is about 15%. Pregnancy-induced hypertension tends to recur in subsequent pregnancy with some mothers remain hypertensive following a pregnancy complicated by pregnancy-induced hypertension.

Pre-eclampsia

Hypertension and proteinuria (protein in the urine) is the most common manifestation of pre-eclampsia and they may present late or mild. Proteinuria in pregnancy may be caused by urinary tract infection but the possibility of pre-eclampsia must also be considered even though the BP is mildly raised. Manifestation of pre-eclampsia (including eclampsia) may present before, during or after the delivery.

others may present with headache, visual disturbance, abdominal pain, nausea, vomiting or rapidly progressive oedema (skin tissue swelling). Unfortunately most mothers are asymptomatic thus making clinical evaluation difficult. Mothers should be educated to look for signs of pre-eclampsia and empowered to take further action. This condition if left untreated and poorly monitored could lead to eclampsia or seizure. This is detrimental to the mother and fetus. The kidney could be affected and blood disorders may occur leading to bleeding and this aggravated with the occurrence of placenta abruption (tearing of the attachment of placenta). The commonest causes of death in pre-eclampsia are cerebral haemorrhage (bleeding in the brain) and adult respiratory distress syndrome (a serious form of lung injury). The fetus may suffer from asphyxia, growth retardation and death.

Eclampsia

Eclampsia is described as epileptic seizure occurring in association with features of pre-eclampsia as described above. Seizure due to epilepsy or other condition such as biochemical imbalance and hypoglycaemia must be excluded before eclampsia is diagnosed. In some circumstances Pre-eclampsia may not be clinically overt and diagnosis can only be made in retrospective. More than one third of women experienced their first convulsion before the development of hypertension and proteinuria. Pregnant teenagers are three times more to suffer convulsion compared to older women. Complication of eclampsia includes stroke caused by cerebral artery spasm and oedema (swelling) of the brain that usually resolves but there are some women who experienced permanent neurological damage.

Screening and Measurement

Hypertension is defined as a systolic blood pressure (BP) > 140mmHg and/or BP > 90mmHg. Isolated raised BP must be taken seriously and proteinuria screened to look for the emergence of pre-eclampsia. Significant proteinuria in pregnancy is defined as > 300mg protein in a 24 hours urine sample or a spot urine protein-creatinine ratio > 30mg/mmol. If dipstick is the only test available, 1+ (30mg/dl) is often but not always associated with > 300mg/day proteinuria. Other than monitoring of BP and urine protein, weight and oedema are associated with pre-eclampsia. Monitoring of renal and liver function is also part of the management to ensure complication does not occur.

High risk women need close monitoring and early referral to secondary or tertiary centre early in the pregnancy.


Screening area in an antenatal clinic

Measuring blood pressure is done routinely in an antenatal clinic.

Management

Women who had previous history of :

  1. Pregnancy induced hypertension or pre-eclampsia
  2. Essential or chronic hypertension
  3. Diabetes mellitus
  4. Renal disease

Should be given aspirin 75mg daily from 12 weeks till delivery. There is clinical evidance that this would have clinical benefit for the pregnancy.

The drugs of choice in pregnancy are still methyldopa and labetolol. Women with pre-existing hypertension may need to change their treatment during pregnancy. Angiotensin Receptor Blocker (ARB) and Angiotension Converting Enzyme Inhibitor (ACEI) are contraindicated in pregnancy. Treatment of hypertension in pregnancy is solely for maternal safety. Is does not reduce the risk of the development of pre-eclampsia or perinatal mortality nor improve fetal growth. Screening for secondary causes if hypertension is present before 20 weeks of gestation is essential. After 16 weeks, screening for pre-eclampsia should be done in all women with hypertensive disorders in pregnancy regardless of age and other risk factors.

Treatment target varies from one centre to another. In other not to compromise uteropalcental circulation, diastolic BP should not be lower than 90mmHg. In pre-eclampsia, regardless of mild or severe, referral to an Obstetrician is mandatory and patient is managed in a shared care system with the primary care physician. In an uncomplicated case, delivery should be aimed 38-40 weeks. All eclampsia cases must be treated in hospital with specialist and good neonatal intensive care unit back up. Decision to deliver the fetus is based on the obstetrician’s judgment and need to be individualized in every case.

Post delivery care

Post partum women with hypertensive disorders in pregnancy are advised to have their BP checked regularly at local clinics. BP tends to normalized in women with pregnancy-induced hypertension after 6 weeks of delivery but it may take a longer time to go back to normal. The dose of antihypertensive drug should be stopped gradually and not abruptly. There are cases where there is persistent hypertension. Therefore regular check up is needed and treatment as indicated. Methyldopa postpartum should be avoided because of high risk of depression.

Women with pre-existing hypertension may revert to their pre-pregnancy hypertension treatment. ACE inhibitors and angiotensin receptor blockers is safe during breastfeeding. Diuretics are usually avoided in breastfeeding mothers to prevent increasing thirst. Aggravation of hypertension after delivery can occur and should be taken seriously as this may indicate eclampsia (which as mentioned can happen post delivery). Chronic hypertension is diagnosed if the blood pressure emains elevated after 3 months.

Women predisposed to hypertensive disorders in pregnancy and pre-eclampsia are predisposed to cardiovascular disease in later life. Longterm follow-up is therefore advisable. Women with pre-existing hypertension are advised to have their blood pressure well controlled at least 3 months before the next conception.


Fetal compromise can occur if hypertension in pregnancy is managed well.

 

Last Reviewed : 26 April 2012
Writer : Dr. Sri Wahyu Taher
Reviewer : Dr. Haris Njoo Suharjono

 

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